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Fluoride prolonged release preparations for topical use.

M Friedman

    Journal of Dental Research
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A novel delayed fluoride (F) release preparation was developed using ethyl cellulose and silicone polymers for sustained F delivery. This innovation offers prolonged topical fluoride availability for enhanced dental health applications.

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    Area of Science:

    • Materials Science
    • Biomaterials
    • Dental Materials

    Background:

    • Topical fluoride application is crucial for dental caries prevention.
    • Conventional fluoride delivery systems may lack sustained release properties.
    • Need for advanced delivery systems ensuring prolonged fluoride availability.

    Purpose of the Study:

    • To develop a novel delayed fluoride (F)-releasing preparation for topical dental use.
    • To investigate the sustained release characteristics and influencing factors of the new preparation.

    Main Methods:

    • Sodium fluoride (NaF) was embedded in ethyl cellulose and silicone polymer matrices.
    • Chewing gum and orthodontic plates were utilized as delivery vehicles.
    • Fluoride release kinetics were analyzed, identifying diffusion as the primary release mechanism.

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    Main Results:

    • Sustained fluoride release was achieved through embedding NaF in nontoxic, insoluble polymers.
    • Release rate was dependent on fluoride solubility, concentration, and effective surface area.
    • Demonstrated prolonged fluoride availability at a controlled level of 0.06–0.5 mg/day.

    Conclusions:

    • A new delayed-release topical fluoride preparation was successfully developed.
    • The formulation ensures sustained and controlled fluoride delivery via diffusion.
    • This technology holds promise for enhanced caries prevention strategies.