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Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Updated: May 13, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

Human preleukemia.

H P Koeffler, D W Golde

    Annals of Internal Medicine
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Preleukemia, a syndrome of hematopoietic dysfunction, precedes acute myelogenous leukemia. It involves abnormal blood cell maturation and is considered an early phase of leukemia.

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    Area of Science:

    • Hematology
    • Oncology
    • Stem Cell Biology

    Background:

    • Preleukemia is characterized by hematopoietic dysfunction preceding acute myelogenous leukemia (AML).
    • Clinical presentation includes pancytopenia and symptoms from decreased blood elements.
    • Bone marrow often shows hypercellularity with dysplastic changes in precursors.

    Purpose of the Study:

    • To define preleukemia as a distinct clinical entity.
    • To differentiate preleukemia from AML predisposition syndromes.
    • To conceptualize preleukemia as an early stage of AML.

    Main Methods:

    • Clinical observation and characterization of preleukemic syndrome.
    • Morphologic analysis of bone marrow precursors.
    • Distinguishing preleukemia from other myelodysplastic conditions.

    Main Results:

    • Preleukemia exhibits variable pancytopenia and morphologic abnormalities in hematopoietic precursors.
    • The neoplastic clone is established and predominant during the preleukemic phase.
    • Preleukemia demonstrates ineffective hematopoiesis due to impaired cell maturation.

    Conclusions:

    • Preleukemia is a clonal hematopoietic stem cell neoplasm.
    • It represents a progressive impairment of precursor cell maturation.
    • Preleukemia is best understood as an early phase of acute myelogenous leukemia.