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Related Experiment Videos

Serum prolactin and opiate withdrawal.

M S Gold, A L Pottash, L B Finn

    Psychiatry Research
    |May 1, 1980
    PubMed
    Summary

    Opiate withdrawal is linked to decreased serum prolactin (PRL), challenging the dopamine hyperactivity hypothesis. A noradrenergic hyperactivity model is proposed for withdrawal symptoms.

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    Area of Science:

    • Neurobiology
    • Endocrinology
    • Addiction Medicine

    Background:

    • The dopamine hyperactivity hypothesis attempts to explain opiate withdrawal.
    • Serum prolactin (PRL) levels are influenced by dopaminergic activity.

    Purpose of the Study:

    • To investigate the dopamine hyperactivity hypothesis in opiate withdrawal using serum prolactin (PRL) measurements.
    • To explore the neurobiological underpinnings of opiate withdrawal and its symptoms.

    Main Methods:

    • Serum PRL was measured in 21 male methadone addicts during opiate withdrawal.
    • Measurements were repeated after clonidine suppression of withdrawal symptoms and 4 weeks drug-free.

    Main Results:

    • Serum PRL levels were significantly decreased during opiate withdrawal and after clonidine treatment compared to baseline.
    • These findings suggest dopaminergic hyperactivity may not directly correlate with opiate withdrawal symptoms.

    Conclusions:

    • The dopamine hyperactivity hypothesis for opiate withdrawal is not supported by these PRL data.
    • A noradrenergic hyperactivity hypothesis is proposed as a more fitting explanation for the neurobiology of opiate withdrawal.

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