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Related Experiment Videos

Pulmonary infiltrates in leukemia.

M F Tenholder, R G Hooper

    Chest
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Opportunistic infections are common in leukemia patients. Diffuse lung infiltrates during treatment are most likely caused by opportunistic organisms, while local infiltrates are often bacterial.

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    Area of Science:

    • Pulmonology
    • Infectious Diseases
    • Hematology

    Background:

    • Immunocompromised patients, particularly those with leukemia, are susceptible to opportunistic infections.
    • Parenchymal lung infiltrates are a common radiographic finding in these patients.
    • Understanding the causes of these infiltrates is crucial for appropriate management.

    Purpose of the Study:

    • To determine the incidence of opportunistic infections in adult leukemia patients.
    • To characterize the radiographic patterns of these infections.
    • To evaluate the diagnostic value of biopsies in identifying opportunistic infections.

    Main Methods:

    • Retrospective review of inpatient records for 139 adult leukemia patients.
    • Analysis of 98 identified parenchymal infiltrates (local and diffuse).

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  • Correlation of radiographic findings with tissue biopsies, autopsies, and treatment response.

    • Main Results:

    • Opportunistic organisms were responsible for 13% of local infectious infiltrates but 93% of diffuse infectious infiltrates during treatment.
    • Non-infectious causes accounted for 65% of diffuse disease episodes.
    • Biopsies were most valuable for diffuse disease during treatment when non-infectious causes were unlikely.

    Conclusions:

    • The etiology of lung infiltrates in leukemia patients varies significantly between local and diffuse patterns.
    • Diffuse infiltrates during treatment in leukemia patients strongly suggest opportunistic infections.
    • Biopsy utility for diagnosing opportunistic infections is highest in diffuse disease during treatment.