[Histological grading and typing in osteosarcoma. Comparison with the survival time of 22 patients]

Histological grading from I--III was carried out for 22 osteosarcomas. There was a positive correlation between higher histological grade of differentiation and higher rate of 2-years-survival. The death rate was 3,7 times higher for osteosarcomas of grade III than for grade I and II tumors. However, no significant differences as to prognosis and age of the patients, localization of tumor metastases, various stages and kind of therapy became evident. In spite of distinct regional differences, as subclassification according to 6 subtypes proposed by Scranton et al. (1975) was possible in all our cases. Statistically significant correlations between these subtypes of osteosarcoma and differences in survival time could not be found, neither for our own limited material, nor for the combined material, including the cases of Scranton et al.