Prostaglandin as a mediator of bone resorption induced by experimental tooth movement in rats

Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment. Prostaglandin E1 or E2 solutions injected in gingiva lying near the upper first molar caused the appearance of osteoclasts and bone resorption.