Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analysis of growth delay data: potential pitfalls.

A C Begg

    The British Journal of Cancer. Supplement
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Tumor growth delay curves can be misleading due to factors like the "tumor bed effect" and slow debris clearance. Standardizing tumor size and using individual animal data is crucial for accurate cell killing assessments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Calcification of the left auricle; report of a case.

    The New Zealand medical journal·2010
    Same author

    OBSERVATIONS ON THE VACCINE TREATMENT OF A SERIES OF CASES OF STAPHYLOCOCCIC INFECTIONS.

    British medical journal·2010
    Same author

    The intervertebral disc and low backache.

    The New Zealand medical journal·2010
    Same author

    Myelography in lumbar intervertebral disk lesions; a correlation with operative findings.

    The British journal of surgery·2010
    Same author

    Cisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor.

    Cancer chemotherapy and pharmacology·2007
    Same author

    Hypoxia in head and neck cancer: how much, how important?

    Head & neck·2005

    Area of Science:

    • Oncology
    • Tumor Biology
    • Radiotherapy Research

    Background:

    • Accurate assessment of treatment efficacy in oncology relies on understanding tumor growth kinetics.
    • Tumor growth delay curves are a common metric, but their interpretation can be complex.
    • Factors influencing tumor regrowth can obscure the direct relationship between treatment-induced cell killing and observed delay.

    Purpose of the Study:

    • To analyze theoretical aspects of tumor growth delay curves that impact the relationship between delay and cell killing.
    • To compare theoretical models with real experimental data.
    • To identify potential confounding factors in the interpretation of tumor growth delay.

    Main Methods:

    • Theoretical analysis of factors affecting tumor growth curves.

    Related Experiment Videos

  • Comparison of theoretical predictions with experimental data from tumor models.
  • Evaluation of the impact of 'tumor bed effect', debris clearance, and averaging growth curves on delay measurements.

    • Main Results:

    • Tumor bed effects, potentially due to vasculature damage, can cause slower growth dependent on endpoint size.
    • Slow clearance of dead cells can mimic a tumor bed effect.
    • Averaging growth curves can falsely suggest slower regrowth, and treatment delay is size-dependent under Gompertzian growth.

    Conclusions:

    • The interpretation of tumor growth delay requires careful consideration of the 'tumor bed effect' and post-treatment debris clearance.
    • Standardizing tumor size at treatment and analyzing individual animal data are essential for accurate assessment of treatment efficacy.
    • Misinterpretation of growth delay curves can lead to inaccurate conclusions about cell killing and treatment effectiveness.