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[Prolactin and sterility (author's transl)].

P Santeler, J Martin, G Daxenbichler

    Wiener Klinische Wochenschrift
    |July 4, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Hyperprolactinemia in women causes reproductive dysfunction. Lowering prolactin levels to 40 ng/ml can restore ovulation, but long-term treatment is often needed for sustained fertility.

    Area of Science:

    • Reproductive Endocrinology
    • Clinical Gynecology

    Context:

    • Hyperprolactinemia is associated with infertility in women.
    • A systematic approach is needed for diagnosis and management.
    • Established diagnostic and therapeutic protocols are essential.

    Purpose:

    • To investigate the relationship between hyperprolactinemia and female infertility.
    • To evaluate the efficacy of treatment strategies for hyperprolactinemia-induced reproductive dysfunction.
    • To determine the optimal prolactin serum level for spontaneous ovulation.

    Summary:

    • 91 infertile women with hyperprolactinemia were studied between 1975-1979.
    • A differentiated clarification and therapy scheme was implemented.
    • 32 pregnancies were achieved in 24 patients through medication or surgery.

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  • Reproductive dysfunction recurred post-pregnancy, worsening with elevated prolactin levels.
  • A prolactin level of 40 ng/ml appears necessary for spontaneous ovulation.

    • Impact:

    • Demonstrates the reversibility of hyperprolactinemia-induced infertility.
    • Highlights the need for long-term management of hyperprolactinemia.
    • Establishes a target prolactin level for ovulation induction.