Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pregnancy and diabetes: a survey.

L Mølsted-Pedersen

    Acta Endocrinologica. Supplementum
    |January 1, 1980
    PubMed
    Summary

    Centralizing diabetes care in pregnancy significantly reduced infant mortality and major congenital malformations. Poor pre-pregnancy diabetic control may increase risks for birth defects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Proposed diagnostic thresholds for gestational diabetes mellitus according to a 75-g oral glucose tolerance test. Maternal and perinatal outcomes in 3260 Danish women.

    Diabetic medicine : a journal of the British Diabetic Association·2003
    Same author

    Perinatal complications in women with gestational diabetes mellitus.

    Acta obstetricia et gynecologica Scandinavica·2001
    Same author

    Clinical impact of mild carbohydrate intolerance in pregnancy: a study of 2904 nondiabetic Danish women with risk factors for gestational diabetes mellitus.

    American journal of obstetrics and gynecology·2001
    Same author

    Prevalence of nocturnal hypoglycemia in first trimester of pregnancy in patients with insulin treated diabetes mellitus.

    Acta obstetricia et gynecologica Scandinavica·2000
    Same author

    Oral hypoglycaemic agents in 118 diabetic pregnancies.

    Diabetic medicine : a journal of the British Diabetic Association·2000
    Same author

    Urinary albumin excretion and 24-hour blood pressure as predictors of pre-eclampsia in Type I diabetes.

    Diabetologia·2000

    Area of Science:

    • Obstetrics and Gynecology
    • Endocrinology
    • Perinatology

    Background:

    • Pregnancy complicated by diabetes presents significant risks to both mother and infant.
    • Historically, high perinatal mortality rates were associated with diabetic pregnancies.
    • Congenital malformations represent a substantial proportion of perinatal deaths in this population.

    Purpose of the Study:

    • To analyze trends in perinatal mortality and congenital malformations in diabetic pregnancies over 34 years.
    • To evaluate the impact of centralized diabetes management on pregnancy outcomes.
    • To investigate the association between pre-pregnancy diabetic control and the incidence of congenital malformations.

    Main Methods:

    • Retrospective analysis of 1885 infants born to diabetic mothers between 1946 and 1978.
    • Comparison of perinatal mortality rates over time.
    • Assessment of congenital malformation rates based on the location of pre-pregnancy diabetes management.

    Main Results:

    • Perinatal mortality decreased significantly from 22.1% to 4.4% during the study period.
    • Congenital malformations accounted for 50% of perinatal deaths.
    • Infants of mothers with specialized pre-pregnancy diabetes care had a lower rate of major congenital malformations (5.6%) compared to those managed elsewhere (12.2%).

    Conclusions:

    • Centralized management of diabetic pregnancies is crucial for improving outcomes.
    • Effective pre-pregnancy diabetic control is associated with a reduced risk of congenital malformations.
    • Poor glycemic control before conception may be a teratogenic factor in diabetic pregnancies.

    Related Experiment Videos