Nephrotoxicity of drugs, evaluated by renal enzyme excretion studies

Via various pathways, urinary enzymatic activities are changed by drugs. Nephrotoxic effects may be determined by such investigations. Numerous experimental series have formed the basis for the clinical application of this method. The pertinent data collected with analgesics and antibiotics, alone or in combinations, are discussed in this paper. The data from the literature were compared with personal investigations, in animals as well as in man. It is concluded that - under certain precautions - the nephrotoxicity of drugs can be evaluated by renal enzyme excretion studies.