Clofibrate and the development of rats

The peri- and postnatal effects of Clofibrate (CPIB) were studied in Wistar-H-Riop rats. 150 mg/kg/day of CPIB given to mothers from 16th gestational day to the 22nd day post partum decreased the birth-weight and increased the liver-weight of the young rats the and perinatal mortality. This effect was studied in the offspring of dams treated during the last week of pregnancy or in different periods of lactation. Increased liver weight was found in the newborn at the end of treatment period however, it disappeared after 1 week without treatment.