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Related Experiment Videos

Occlusal dysfunction and stress. An experimental study in macaque monkeys.

E Budtz-Jørgensen

    Journal of Oral Rehabilitation
    |January 1, 1981
    PubMed
    Summary

    Creating a dysfunctional bite in monkeys led to increased stress hormones, suggesting a link between poor occlusion and bruxism (teeth grinding) due to emotional stress.

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    Area of Science:

    • Biomedical Science
    • Dental Research
    • Stress Physiology

    Background:

    • Dysfunctional occlusal relationships can impact physiological stress responses.
    • Bruxism, or teeth grinding, is often associated with emotional stress.
    • Understanding the physiological mechanisms linking occlusion and stress is crucial.

    Purpose of the Study:

    • To investigate the physiological effects of experimentally induced dysfunctional occlusal relationships in a primate model.
    • To determine if occlusal disturbances can trigger stress responses, specifically elevated cortisol levels.
    • To explore the potential link between occlusal dysfunction and bruxism associated with emotional stress.

    Main Methods:

    • Induction of occlusal dysfunction in six Macaca irus monkeys using occlusal splints.
    • Measurement of plasma and 24-hour urinary cortisol levels using competitive protein-binding analysis.
    • Monitoring of physiological parameters including urinary volume, body weight, and dental changes over a 3-week period.

    Main Results:

    • A significant, approximately two-fold increase in 24-hour urinary cortisol excretion rates immediately after splint insertion.
    • Sustained elevation of urinary cortisol throughout the 3-week experimental period.
    • Significant decreases in urinary volume and body weight, with increased tooth mobility and wear facets observed.

    Conclusions:

    • Experimentally induced occlusal dysfunction in primates leads to a marked increase in physiological stress markers.
    • This animal model provides evidence supporting the hypothesis that occlusal disharmony can induce bruxism related to emotional stress.
    • The findings highlight the intricate connection between dental occlusion, stress physiology, and potential behavioral responses like bruxism.

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