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Related Experiment Videos

Masseter myopathy following systemic corticosteroid administration: an experimental study.

M Silbermann, R Ludatscher, S Finkelbrand

    Oral Surgery, Oral Medicine, and Oral Pathology
    |December 1, 1980
    PubMed
    Summary

    Triamcinolone hexacetonide, a cortisol analogue, induced degenerative changes in masseter muscles of young mice. These myopathic alterations may impact mandible development.

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    Area of Science:

    • Muscle physiology
    • Histopathology
    • Endocrinology

    Background:

    • Corticosteroids like triamcinolone hexacetonide are synthetic cortisol analogues.
    • Immature musculoskeletal development is sensitive to hormonal influences.

    Purpose of the Study:

    • To investigate the ultrastructural effects of alternate-dose triamcinolone hexacetonide on masseter muscles in immature mice.
    • To explore potential links between corticosteroid-induced myopathy and mandibular growth inhibition.

    Main Methods:

    • Immature A/J mice received alternate-day doses of triamcinolone hexacetonide.
    • Masseter muscles were analyzed using ultrastructural examination.

    Main Results:

    • Degenerative changes observed in myofibers, including Z disc alterations and myofilament disintegration.

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  • Mitochondrial loss, glycogen depletion, and nuclear displacement were noted.
  • Enhanced collagen fibrillogenesis, capillary endothelial cell hypertrophy, and neuromuscular junction alterations occurred.

    • Conclusions:

    • Alternate-day administration of triamcinolone hexacetonide induces significant myopathic changes in developing masseter muscles.
    • These muscle changes may contribute to the observed retardation of mandibular growth in young mice.