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Basal and stimulated serum immunoreactive trypsin in normal subjects
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1980
Summary
Fasting serum immunoreactive trypsin (IRT) levels in healthy individuals did not change after meals or glucose. Only secretin injection significantly increased serum IRT, suggesting pancreatic duct engorgement.
Area of Science:
- Biochemistry
- Gastroenterology
- Endocrinology
Background:
- Serum immunoreactive trypsin (IRT) is a marker of pancreatic function.
- Understanding factors influencing IRT levels is crucial for diagnostic accuracy.
Purpose of the Study:
- To investigate the effect of various stimuli on serum IRT concentrations in healthy subjects.
- To determine if meals or secretin administration alter fasting IRT levels.
Main Methods:
- Fasting serum IRT was measured in 35 healthy individuals.
- IRT levels were assessed after secretin, Lundh meal, protein meal, or glucose load.
- Radioimmunoassay (RIA) was used for serum IRT quantification.
Main Results:
- Fasting serum IRT was 25.8 +/- 9 ng/ml.
- No significant changes in IRT were observed after protein meal, Lundh meal, or glucose load.
- Intravenous secretin injection caused a significant increase in serum IRT levels.
Conclusions:
- Secretin administration, not standard meals or glucose, significantly elevates serum IRT in healthy individuals.
- The rise in IRT post-secretin is likely due to pancreatic duct engorgement and trypsinogen regurgitation.
- This finding has implications for interpreting IRT levels in pancreatic function tests.