Systemic hypertension: complication of intra-arterial cis-diammine dichloroplatinum (II) infusion

Intra-arterial Cis-diammine dichloroplatinum (II) administered to five patients produced systemic and sustained hypertension in four of them. This finding persisted for six months despite discontinuation of the drug. This complication has not been observed in patients receiving the drug by the intravenous route. Possible etiologic factors are discussed.