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Obstructive sleep apnea in Treacher-Collins syndrome
The Cleft Palate Journal
|January 1, 1981
Summary
Treacher-Collins syndrome patients often have obstructive sleep apnea. Surgical correction of micrognathia can resolve sleep apnea and improve behavior and attention.
Area of Science:
- Genetics and Developmental Biology
- Pediatric Pulmonology
- Craniofacial Surgery
Background:
- Treacher-Collins syndrome is primarily known for hearing and surgical issues.
- Craniofacial anomalies in Treacher-Collins syndrome can lead to respiratory problems, particularly obstructive sleep apnea (OSA), even in older children.
Observation:
- An 8-year-old with Treacher-Collins syndrome exhibited behavioral issues, poor attention, daytime sleepiness, and severe obstructive sleep apnea (OSA).
- Symptoms included abnormal sleep behaviors like rocking and periods of chest movement without airflow, confirmed by ICU monitoring and cineradiography.
Findings:
- The patient underwent orthognathic surgery with rib bone grafts and mandibular advancement.
- Post-surgery, the obstructive sleep apnea (OSA) resolved, along with associated symptoms.
Implications:
- Micrognathia in Treacher-Collins syndrome significantly increases the risk of obstructive sleep apnea (OSA).
- Surgical correction of craniofacial deformities offers cosmetic benefits and effectively resolves OSA, improving cognitive and behavioral outcomes.