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Human platelet monoamine oxidase and the menstrual cycle
Psychiatry Research
|December 1, 1980
Summary
Menstrual cycle variations significantly impact platelet monoamine oxidase (MAO) activity in women. Peak MAO levels were observed during ovulation, with a notable decrease occurring 5-6 days later, highlighting hormonal influences on this enzyme.
Area of Science:
- Endocrinology
- Neuroscience
- Biochemistry
Background:
- Endocrine factors are recognized modulators of platelet monoamine oxidase (MAO) activity.
- Understanding the influence of sex steroid hormones on MAO is crucial for interpreting research findings.
Purpose of the Study:
- To investigate the role of sex steroid hormones in regulating platelet monoamine oxidase (MAO) activity.
- To quantify the menstrual variation in MAO activity throughout the female reproductive cycle.
Main Methods:
- Blood samples were collected twice weekly from 12 women over their menstrual cycles.
- Platelet monoamine oxidase (MAO) activity was assessed using biochemical assays.
Main Results:
- A significant variation in platelet MAO activity was observed across the menstrual cycle.
- Peak MAO activity coincided with the ovulatory interval.
- A nadir in MAO activity was detected 5 to 6 days post-ovulation, showing a mean variation of 17% from peak to nadir.
Conclusions:
- Menstrual cycle phase and associated hormonal fluctuations significantly influence platelet MAO activity in women.
- These findings have important implications for the design and interpretation of psychiatric research involving MAO levels.