[A modified therapy of hayfever with a depot-preparation (author's transl)]

70 patients with clinically and immunologically verified grass pollen allergy received immunotherapy for the first time in 1977 and 1978. The 70 patients were divided into 3 groups. Group 1 received 18 injections of a 7 grass pollen extract (semi-depot, Allpyral). Group 2 was treated with 3 injections of a tyrosine adsorbed grass pollen vaccine (Pollagen) immediately preseasonal and Group 3 received 5 injections of the same. Therapy was from September 1977 to May 1978. All patients completed dairy cards on a daily basis for the 1978 season including data on additional medication and areas visited. The air pollen concentration was monitored at various sites in Vienna and surrounding area. Reviewing the symptoms of the 3 patients we noted stronger symptoms reported in Group 2 than in Group 1. There was no significant difference in severity of symptoms in Group 1 and Group 3. The data indicate that a treatment with a course of 5 injections of a tyrosine adsorbed grass pollen vaccine is better than a course of 3 injections of the same product, and equivalent to a standard course of therapy with a semi-depot product.