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A comparison between different methods for detecting bronchial hyperreactivity. Bronchial hyperreactivity: methods of

C Grassi, L Casali, A Rossi

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1980
    PubMed
    Summary
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    This study compared bronchial hyperreactivity tests in healthy, asthmatic, and rhinitic patients. Asthmatic patients showed significant responses to bronchodilation and running tests, indicating their utility in diagnosing asthma.

    Area of Science:

    • Pulmonology
    • Allergy and Immunology
    • Respiratory Medicine

    Background:

    • Bronchial hyperreactivity is a hallmark of asthma.
    • Assessing bronchial hyperreactivity aids in asthma diagnosis and management.
    • Non-specific bronchostimulation tests are crucial for evaluating airway responsiveness.

    Purpose of the Study:

    • To compare the efficacy of two non-specific bronchostimulation methods (ultrasonic mist and free running) against a bronchodilation test.
    • To evaluate bronchial hyperreactivity in non-smoking normal subjects, asthmatic patients, and rhinitic patients.
    • To analyze ventilatory parameters including FVC, FEV1, MMEF, and Vmax25.

    Main Methods:

    • Bronchodynamic tests were performed on three subject groups: normal (15), asthmatic (23), and rhinitic (16).

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  • Two non-specific bronchostimulation methods (ultrasonic mist, free running) and a bronchodilation test were employed.
  • Ventilatory parameters (FVC, FEV1, MMEF, Vmax25) were measured to assess airway response.

    • Main Results:

    • In asthmatic patients, the bronchodilation test was positive in 65% (FEV1) and 87% (forced flows).
    • The running test was positive in 26% (FEV1) and 61% (forced flows) of asthmatics.
    • Ultrasonic mist induced significant FEV1 drops in 17% and flow reductions in 30% of asthmatics; rhinitic patients showed fewer significant changes.

    Conclusions:

    • Bronchodilation and running tests are effective in identifying bronchial hyperreactivity in asthmatic patients.
    • Ultrasonic mist is a less potent stimulus for inducing hyperreactivity compared to the running test in asthmatics.
    • Rhinitic patients demonstrated lower levels of bronchial hyperreactivity across all tested methods.