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In vivo remineralization using a sustained topical fluoride delivery system.

L J Abrahams, M Yonese, W I Higuchi

Journal of Dental Research

|March 1, 1980

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This study tested a new remineralization system on demineralized teeth. The system effectively increased fluoride uptake in teeth exposed to low fluoride levels.

Area of Science:

Dental research
Biomaterials science
Cariology

Background:

Dental caries is a significant public health issue.
Remineralization therapies aim to repair early tooth decay.
Fluoride is a key agent in preventing and reversing demineralization.

Purpose of the Study:

To evaluate the in vivo efficacy of a novel remineralization system.
To quantify fluoride uptake in demineralized human tooth enamel using the system.

Main Methods:

A controlled in vivo study was conducted using human subjects.
Subjects wore removable partial dentures with demineralized human teeth.
Teeth were exposed to a low fluoride concentration (approx. 1 ppm) for 48 hours.

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Main Results:

The remineralization system demonstrated significant fluoride uptake.
Fluoride levels reached up to 500 ppm within 50-micron depths of experimental sites.
The system was effective under sustained low fluoride exposure.

Conclusions:

The new remineralization system shows promise for in vivo tooth repair.
Sustained low fluoride exposure with this system can lead to substantial remineralization.
Further research into clinical applications is warranted.