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Cefamandole against Bacteroides fragilis
Scandinavian Journal of Infectious Diseases. Supplementum
|January 1, 1980
Summary
Cefamandole, a cephalosporin antibiotic, shows strong activity against Gram-positive and Gram-negative bacteria. Its effectiveness against Bacteroides fragilis supports its use in treating severe hospital-acquired infections, including post-surgical cases.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Cefamandole is a second-generation cephalosporin antibiotic.
- It exhibits significant antimicrobial activity against a broad spectrum of aerobic pathogens.
Purpose of the Study:
- To evaluate the in vitro activity of cefamandole against clinical isolates of Bacteroides fragilis.
- To reinforce the recommendation of cefamandole for prophylaxis and treatment of severe hospital infections.
Main Methods:
- Testing cefamandole susceptibility against 20 recent clinical isolates of Bacteroides fragilis.
- Analyzing susceptibility data in conjunction with known activity against common aerobic pathogens.
Main Results:
- Eighty-five percent of the tested Bacteroides fragilis isolates demonstrated sensitivity to cefamandole.
- Cefamandole exhibits high activity against common Gram-positive and Gram-negative aerobic pathogens.
Conclusions:
- The demonstrated sensitivity of Bacteroides fragilis to cefamandole supports its clinical utility.
- Cefamandole is recommended for prophylaxis and treatment of severe hospital infections, especially post-surgical cases with septicaemia.