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Netilmicin in the treatment of neonates with moderate and severe infections

H Michalsen, K Halvorsen, T Bergan

    Scandinavian Journal of Infectious Diseases. Supplementum
    |January 1, 1980
    PubMed

    Insights

    This study found that combining netilmicin and ampicillin for 7 days effectively treated infections in neonates and infants. The antibiotic combination showed good tolerance and no adverse effects, including no auditory impairment.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Pharmacology

    Background:

    • Neonates and infants are susceptible to serious bacterial infections.
    • Empirical antibiotic therapy is often necessary in this population.
    • Netilmicin, an aminoglycoside, requires careful dosing and monitoring in pediatric patients.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intravenous netilmicin and ampicillin combination therapy in neonates and infants.
    • To assess the incidence of adverse reactions and long-term sequelae, including auditory impairment.

    Main Methods:

    • A prospective study involving 30 neonates and infants treated for verified or suspected infections.
    • Intravenous administration of netilmicin and ampicillin for 7 days.
    • Monitoring of clinical outcomes, bacteriological cultures, and auditory function via Brain Stem Evoked Response at 3 months.

    Main Results:

    • Complete resolution of infection signs and recovery without sequelae in most patients (28/30).
    • Two cases of osteomyelitis showed incomplete resolution.
    • No deaths or adverse reactions to the antibiotic therapy were recorded.
    • No auditory impairment was detected at 3-month follow-up.

    Conclusions:

    • The combination of netilmicin and ampicillin is safe and effective for treating infections in neonates and infants.
    • Netilmicin, when guided by serum concentrations, is a reliable aminoglycoside for this age group.
    • Further studies may be warranted to confirm findings in specific infections like osteomyelitis.

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