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EORTC protocols in prostatic cancer. An interim report

M Pavone-Macaluso, F Lund, J H Mulder

    Scandinavian Journal of Urology and Nephrology. Supplementum
    |January 1, 1980
    PubMed
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    Low-dose Stilboestrol showed comparable efficacy and side effects to other treatments in early prostate cancer. For advanced, hormone-refractory prostate cancer, neither Adriamycin nor Procarbazine demonstrated superiority, with Procarbazine showing higher toxicity.

    Area of Science:

    • Urology
    • Oncology
    • Clinical Pharmacology

    Background:

    • Prostate cancer treatment often involves hormonal therapy.
    • Evaluating alternative hormonal agents and salvage chemotherapy is crucial for improving patient outcomes.

    Purpose of the Study:

    • To compare the efficacy and safety of low-dose Stilboestrol against Cyproterone acetate and Medroxyprogesterone acetate in previously untreated prostate cancer patients.
    • To compare Stilboestrol with Estracyt in a similar patient cohort.
    • To assess the effectiveness of Adriamycin versus Procarbazine in patients with advanced, hormone-refractory prostate cancer.

    Main Methods:

    • Two prospective randomized studies were conducted by the EORTC Urological Group.
    • Study 1: Low-dose Stilboestrol vs. Cyproterone acetate vs. Medroxyprogesterone acetate.

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  • Study 2: Stilboestrol vs. Estracyt. Study 3: Adriamycin vs. Procarbazine in hormone-refractory disease.

    • Main Results:

    • In the first two trials, Stilboestrol demonstrated comparable objective response rates and side effect profiles to Cyproterone acetate, Medroxyprogesterone acetate, and Estracyt, with the exception of gynecomastia.
    • In the third trial for advanced disease, Procarbazine exhibited particularly high toxicity and early mortality.
    • Most patients in the third trial experienced disease progression regardless of treatment with Adriamycin or Procarbazine.

    Conclusions:

    • Low-dose Stilboestrol appears to be a viable option for initial treatment of prostate cancer, offering similar efficacy and tolerability to other agents.
    • Salvage chemotherapy options for hormone-refractory prostate cancer, such as Adriamycin and Procarbazine, show limited efficacy and significant toxicity concerns, particularly with Procarbazine.