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Pathology of prostatic cancer
Scandinavian Journal of Urology and Nephrology. Supplementum
|January 1, 1980
Summary
Prostate cancer exhibits diverse histologic patterns, with poorly differentiated types predominating in advanced stages. Latent prostate carcinomas, often asymptomatic, increase with age and require differentiation from clinical cases.
Area of Science:
- Urologic Oncology
- Pathology
- Epidemiology
Background:
- Prostate carcinoma registry data from 1972-1975 analyzed 6758 cases.
- Patient age distribution shows 52% between 65-75 years, 22% younger than 65.
Purpose of the Study:
- To characterize the histologic types, differentiation, staging, and age distribution of clinical prostatic carcinomas.
- To investigate the prevalence and characteristics of latent and incidental prostate carcinomas.
- To assess tumor behavior and response to therapy.
Main Methods:
- Histologic classification into 4 basic types: highly/poorly differentiated adenocarcinomas, cribriform/solid anaplastic carcinomas.
- Staging according to FLOCKS criteria (Stages B-D).
- Analysis of tumor architecture (uniform vs. pluriform differentiation).
Main Results:
- Predominance of fast-proliferating, poorly differentiated prostatic carcinomas.
- Latent/incidental carcinomas (Stage 0) show high differentiation and low malignancy, increasing with age.
- Approximately 20% of clinical cases present as therapy-resistant tumors; transitional cell carcinomas require differentiation.
Conclusions:
- Prostate cancer heterogeneity necessitates careful histologic evaluation and staging.
- Asymptomatic, low-grade carcinomas are common, particularly in older men.
- Therapy response varies, highlighting the need to identify resistant subtypes and distinct carcinoma types.