Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Rifampicin associated renal dysfunction during antituberculous therapy

A G Need, P J Phillips, F T Chiu

Australian and New Zealand Journal of Medicine

|December 1, 1980

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Performance comparison of Yb:YAG ceramics and crystal gain material in a large-area, high-energy, high average-power diode-pumped laser.

Optics express·2020

Same author

Concentrations of hormones, pharmaceuticals and other micropollutants in groundwater affected by septic systems in New England and New York.

The Science of the total environment·2015

Same author

Osteoporosis in the community: Sensitivity of self-reported estimates and medication use of those diagnosed with the condition.

Bone & joint research·2013

Same author

High-energy, ceramic-disk Yb:LuAG laser amplifier.

Optics express·2012

Same author

Combined sewer overflows: an environmental source of hormones and wastewater micropollutants.

Environmental science & technology·2012

Same author

Biosynthesis of protein products by animal cells. Are growth and non-growth associated concepts valid or useful?

Cytotechnology·2012

Same journal

Gastroenterological Society of Australia, Annual Scientific Meeting, May 1980.

Australian and New Zealand journal of medicine·2020

Same journal

'A touch of sugar'--a dangerous euphemism still alive and well.

Australian and New Zealand journal of medicine·2001

Same journal

Silent myocardial ischaemia following methysergide overdose.

Australian and New Zealand journal of medicine·2001

Same journal

Extensive jugular and upper limb thrombosis in a patient with factor V Leiden mutation and non-Hodgkin's lymphoma.

Australian and New Zealand journal of medicine·2001

Same journal

Visual loss as the presenting feature of giant cell arteritis.

Australian and New Zealand journal of medicine·2001

Same journal

Lymphoproliferative disease causing angioedema--an uncommon association.

Australian and New Zealand journal of medicine·2001

See all related articles

Continuous rifampicin therapy can cause kidney damage, distinct from light chain proteinuria. Ethambutol therapy is linked to elevated plasma urate levels in tuberculosis patients.

Area of Science:

Nephrology
Pharmacology
Infectious Diseases

Background:

Rifampicin is a key antibiotic for tuberculosis treatment.
Intermittent rifampicin use is associated with flu-like symptoms and acute kidney injury.
The mechanism of rifampicin-induced renal damage requires further elucidation.

Observation:

A case study details partially reversible renal damage from continuous rifampicin therapy.
This damage was not attributed to light chain proteinuria.
Retrospective analysis of 89 tuberculosis patients was conducted.

Findings:

Continuous rifampicin therapy can lead to insidious, partially reversible renal damage.
Evidence suggests light chain proteinuria is not the cause of this renal damage.

Related Experiment Videos

Increased plasma urate concentration was commonly observed with ethambutol therapy.

Implications:

Continuous rifampicin therapy requires careful renal function monitoring.
The findings differentiate rifampicin-induced nephrotoxicity from other mechanisms.
Understanding ethambutol's effect on urate levels may inform co-treatment strategies.