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Related Experiment Videos

Hand changes in primary biliary cirrhosis

D J O'Connell, W J Marx

    Radiology
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Radiographic hand findings in primary biliary cirrhosis reveal frequent erosive arthritis and osteopenia. Unreported chondrocalcinosis and hypertrophic osteoarthropathy were also observed in patients with this liver disease.

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    Area of Science:

    • Rheumatology
    • Hepatology
    • Radiology

    Background:

    • Primary biliary cirrhosis (PBC) is a chronic liver disease affecting bile ducts.
    • Skeletal manifestations in PBC are not fully characterized.
    • Hand radiography can reveal important clues to systemic involvement.

    Purpose of the Study:

    • To describe radiographic hand findings in patients with primary biliary cirrhosis.
    • To identify common and uncommon skeletal abnormalities in PBC.
    • To discuss the clinical significance of these radiographic findings.

    Main Methods:

    • Retrospective review of hand radiographs from 13 patients diagnosed with PBC.
    • Analysis of radiographic features including arthritis, osteopenia, lytic defects, chondrocalcinosis, and osteoarthropathy.

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    Main Results:

    • Erosive arthritis was present in 12 of 13 patients.
    • Osteopenia due to hepatic osteodystrophy was observed in 7 patients.
    • Intraosseous lytic defects, chondrocalcinosis (2 patients), and hypertrophic osteoarthropathy (1 patient) were noted.

    Conclusions:

    • Hand radiography reveals a high prevalence of erosive arthritis and osteopenia in PBC.
    • Chondrocalcinosis is a newly reported radiographic finding in primary biliary cirrhosis.
    • Skeletal abnormalities are common in PBC and warrant further investigation.