Prolonged WBC depression after cimetidine in a patient with chronic myelogenous leukemia

A patient with chronic myelogenous leukemia was treated with cimetidine and antibiotics after pneumonectomy. The prolonged suppression of the WBC that followed may be related to cimetidine administration in a stressed patient. Such patients should have periodic white blood cell counts because substituting the cyanoguanidine group for the thiourea group may not eliminate the hematologic effects of the H2 receptor antagonists.