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On the pathology of meningiomas. A study of 412 cases
Abstract:
Some pathological features of tumors arising primarily in the meninges are discussed on the basis of 412 surgically treated meningiomas during the period running from 1964 to 1978. Cases of meningeal sarcomas were not considered. Except for a few cases, pathology and clinical course have been generally in agreement. The incidence of histological types like meningotheliomatous, fibroblastic, angioblastic or atypical meningiomas has been verified in relation to sex, age and intracranial or spinal conventional locations. The problem of recurrencies has been studied either comparing the histological features with the first observation or comparing histopathological types with location and details of surgical procedure. Additional criteria like uni or multifocal origin of the tumors and histological features of the peri-lesional tissues, often harbouring small meningiomatous nests, have been taken into account.
Insights
This study analyzed 412 surgically treated meningiomas, finding that tumor pathology generally aligns with clinical outcomes. Histological types varied by patient demographics and tumor location, influencing recurrence rates.
Area of Science:
- Neurosurgery
- Pathology
- Oncology
Background:
- Meningiomas are tumors arising from the meninges.
- Understanding their pathological features is crucial for predicting clinical course.
Purpose of the Study:
- To analyze pathological features of meningiomas.
- To correlate histological types with patient demographics, tumor location, and recurrence.
- To investigate the significance of multifocal origin and peritumoral tissue in meningioma behavior.
Main Methods:
- Retrospective analysis of 412 surgically treated meningiomas (1964-1978).
- Classification of tumors into histological types: meningotheliomatous, fibroblastic, angioblastic, and atypical.
- Correlation of histological findings with sex, age, tumor location (intracranial vs. spinal), surgical details, and recurrence data.
Main Results:
- Pathology and clinical course showed general agreement in most cases.
- Incidence of histological subtypes varied with sex, age, and tumor location.
- Recurrence rates were influenced by histological type, tumor location, and surgical approach.
- Peritumoral tissues and multifocal origin were considered as additional factors.
Conclusions:
- Histopathological classification provides valuable insights into meningioma behavior.
- Patient demographics and tumor location are significant factors in meningioma presentation and prognosis.
- Detailed surgical procedures and assessment of peritumoral tissues may aid in managing meningioma recurrence.