EEG and behavioral effects of pirenzepine in normal volunteers

Effects of pirenzepine on quantitative EEG, heart rate, blood pressure, critical flicker-fusion frequency, vigilance measures, and symptom reports were studied in 23 adult male volunteers under thirty years of age. Oral single doses ranged from 12.5 to 150 mg. Placebo-controlled studies were done in twelve subjects at 100 mg and in ten subjects at 150 mg. Pirenzepine administration was associated with reduced heart rate, dry mouth, and difficulty in focussing near vision. No systematic central activity of the compound was demonstrated at these doses.