Adsorption of bile acids and lysolecithin by antacids

Several antacids of silicate or Al-Mg-hydroxide type were tested in vitro for adsorption of bile acids and lysolecithin in concentrations up to 4 and 0.4 microMol/ml respectively, using human gastric aspirates. There was a considerable binding of both reflux agents, with mean values from 20 to 76% for bile acids and from 59 to 96% for lysolecithin. Maximal adsorption of both substances was achieved within 30 min. no reliberation could be detected afterwards. Antacids or similar compounds may be of therapeutic efficacy in treating or preventing reflux-induced gastric lesions.