Inhibition of reverse peristalsis of the intestine by domperidone

In two dogs the effect of domperidone (0.5 mg/kg BW i.v.) on retroperistaltism produced by apomorphine (3-10 mg s.c.) was studied. Reverse peristalsis was characterized by strong and long lasting contractions of the duodenum. Domperidone inhibited, in 10 out of 11 experiments, reverse peristalsis and reflux of intestinal contents. It is well known that domperidone inhibits emesis in dogs and humans but it has not been studied whether preceding retroperistaltism is also inhibited. Therefore the effect of domperidone on retroperistaltism was investigated in two dogs.