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Thromboplastin reference preparations

K W Denson

    Scandinavian Journal of Haematology. Supplementum
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Standardizing anticoagulant therapy control is crucial. International reference preparations for thromboplastin sensitivity have been developed and validated since 1967, ensuring reliable calibration and therapeutic monitoring.

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    Area of Science:

    • Medical Laboratory Science
    • Biotechnology
    • Clinical Chemistry

    Background:

    • Standardization of anticoagulant therapy control methods was recognized as essential over 25 years ago.
    • The development of the ratio method enabled comparison of thromboplastin preparation sensitivities.
    • A need for a reference standard (yardstick) for calibration became evident.

    Purpose of the Study:

    • To establish and validate international reference preparations for thromboplastin.
    • To facilitate the standardization of anticoagulant therapy monitoring.
    • To ensure consistent and comparable results across different laboratories and thromboplastin reagents.

    Main Methods:

    • Development and distribution of trial reference preparations starting in 1965.

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  • Conducting international collaborative trials to calibrate thromboplastin preparations.
  • Establishing coded international reference preparations (e.g., 67/40, 68/434, 69/223, 70/178).

    • Main Results:

    • Multiple stable international reference preparations have been established since 1967.
    • These preparations have demonstrated usefulness for calibration and international trials over 9-12 years.
    • Further reference preparations were established in 1979, with ongoing collaborative studies.

    Conclusions:

    • The established international reference preparations are stable and effective for thromboplastin calibration.
    • These standards are vital for the ongoing standardization and control of anticoagulant therapy.
    • Continued international collaboration is essential for maintaining and advancing these standardization efforts.