Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The acute inflammatory process in copper-deprived rats

R Milanino, A Conforti, M E Fracasso

    Agents and Actions. Supplements
    |January 1, 1980
    PubMed
    Summary

    Copper deficiency exacerbates inflammatory responses, including foot swelling and chest inflammation, in rats. This suggests copper plays a crucial role in modulating acute inflammation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

    Physical review letters·2026
    Same author

    Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Assisted reproductive technology and esophageal atresia: Dangerous liaisons?

    Journal of pediatric surgery·2025
    Same author

    Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Persistent Low-Output Neonatal Chylothorax: How Long Are We Justified to Wait for Pleurodesis in Partial Responders?

    Pediatric pulmonology·2025
    Same author

    Reproductive outcome after frozen embryo transfer with hormone replacement therapy according to luteal-phase support protocol: systematic review and network meta-analysis of randomized controlled trials.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025

    Area of Science:

    • Biochemistry
    • Immunology
    • Toxicology

    Background:

    • Copper is implicated in both experimental and human inflammatory conditions.
    • Existing data suggest a significant role for copper in the inflammatory process.

    Purpose of the Study:

    • To investigate the role of copper in the inflammatory process.
    • To determine the effect of copper deficiency on carrageenan-induced inflammation in rats.

    Main Methods:

    • Rats were fed copper-deficient diets (0.2-0.8 p.p.m.) for varying durations (1-5 months).
    • Carrageenan-induced foot oedema and pleurisy models were used to assess inflammation.
    • Different copper concentrations and time points were evaluated.

    Main Results:

    Related Experiment Videos

    • Copper deficiency led to an enhancement of the inflammatory reaction.
    • The observed enhancement in inflammation was dependent on both the duration of copper deficiency and the level of copper restriction.
    • Inflammatory responses, including foot oedema and pleurisy, were significantly increased in copper-deficient rats.

    Conclusions:

    • Endogenous copper may play a key role in modulating acute inflammatory processes.
    • Copper deficiency can potentiate inflammatory reactions, highlighting the importance of copper homeostasis in immune responses.