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Trans fatty acids in tumor development and the host survival
Journal of the National Cancer Institute
|July 1, 1981
Summary
Trans fatty acids, like elaidic acid, promote Ehrlich tumor cell growth and reduce host survival rates in mice. This suggests a potential link between trans fats and cancer development.
Area of Science:
- Oncology
- Nutritional Science
- Biochemistry
Background:
- Trans fatty acids are prevalent in Western diets.
- A potential link between trans fatty acids and cancer incidence has been suggested.
- Ehrlich ascites tumor is a model for cancer research.
Purpose of the Study:
- To investigate the role of trans fatty acids in Ehrlich tumor cell development.
- To determine the impact of elaidic acid on tumor cell proliferation and host survival.
Main Methods:
- Inbred CBA mice were used as the animal model.
- Animals were fed diets rich in either elaidic acid (trans) or oleic acid (cis).
- Tumor cell proliferation was assessed by thymidine incorporation.
- Host survival rates were monitored.
Main Results:
- Elaidic acid-rich diet led to increased thymidine incorporation in tumor cells.
- Tumors from elaidic acid-fed mice showed higher incorporation into the acid-insoluble fraction.
- Host survival was reduced by 23-45% in elaidic acid-fed mice.
Conclusions:
- Dietary elaidic acid promotes Ehrlich tumor cell proliferation.
- Trans fatty acids may negatively impact host survival in cancer-bearing animals.
- Further research is warranted on the oncogenic potential of trans fatty acids.