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The inorganic phase in dentinogenesis imperfecta

B Kerebel, G Daculsi, J Menanteau

    Journal of Dental Research
    |September 1, 1981
    PubMed
    Summary

    Dentinogenesis imperfecta affects tooth inorganic composition, showing fewer, normal-sized crystallites and altered mineral content. Increased water content is linked to lattice water in this condition.

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    Area of Science:

    • Biomineralization
    • Dental Science
    • Materials Science

    Background:

    • Dentinogenesis imperfecta is a genetic disorder affecting dentin formation.
    • Understanding the inorganic phase alterations is crucial for managing this condition.

    Purpose of the Study:

    • To investigate the characteristics of the inorganic phase in dentinogenesis imperfecta.
    • To compare the mineral composition and crystallite structure with normal dentin.

    Main Methods:

    • Correlated techniques including high-resolution transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared absorption spectroscopy, thermogravimetry, and chemical and electron microprobe analyses were employed.
    • Mineral content, Ca/P ratio, Mg content, and crystallite size and number were analyzed.

    Main Results:

    • Crystallites in dentinogenesis imperfecta were of normal size but less numerous than in normal dentin.
    • Significant differences in mineral content were observed, including a higher Ca/P ratio, reduced Ca and P, and a substantial loss of Mg.
    • The inorganic phase primarily consisted of poorly crystallized carbonated apatite, with increased water content potentially due to lattice water.

    Conclusions:

    • Dentinogenesis imperfecta is characterized by altered inorganic phase composition and structure.
    • The findings suggest a link between increased water content and the inorganic phase in dentinogenesis imperfecta.
    • Further research into the specific mechanisms of mineral alteration is warranted.

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