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Updated: Aug 19, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
Effect of nutrition on nonspecific inflammatory and specific immune host defense systems
Abstract:
A truly prophylactic regimen for reducing the incidence of nosocomial infections would attempt to prevent the development of acquired deficiencies in host defenses. Monocyte function is a pivotal link between the specific immune system and non-specific inflammatory responses. We have found that decreased monocyte production of plasminogen activator correlates with a decrease in specific immune function and complement interaction. Simultaneously, monocyte generation of tissue procoagulant factor increases. Use of nutritional support of antibiotics in a judicious fashion may prevent those trauma-mediated or disease-mediated alterations in monocyte function which correlate with development of nosocomial infections.
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