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Acute oesophagitis due to emepronium bromide

L C Hillman, B A Scobie, E W Pomare

    The New Zealand Medical Journal
    |July 8, 1981
    PubMed
    Summary
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    Emepronium bromide, used for urinary issues, can cause severe esophageal inflammation and pain. Stopping the medication led to spontaneous symptom resolution in six documented cases.

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Emepronium bromide is prescribed for urinary symptoms.
    • Esophageal adverse events associated with this medication are not widely recognized.

    Purpose of the Study:

    • To report cases of acute esophagitis linked to emepronium bromide therapy.
    • To highlight the potential for emepronium bromide to cause esophageal injury.

    Main Methods:

    • Retrospective case series.
    • Endoscopic documentation of esophageal inflammation and ulceration.
    • Clinical assessment of symptoms and medication history.

    Main Results:

    • Six patients developed acute esophagitis during emepronium bromide treatment.
    • Symptoms included severe retrosternal pain and dysphagia.

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  • All symptoms resolved after discontinuing emepronium bromide.

    • Conclusions:

    • Emepronium bromide can induce significant esophageal inflammation and ulceration.
    • Clinicians should be aware of this potential adverse effect.
    • Prompt discontinuation of the drug is recommended if esophagitis is suspected.