Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA and kidney stone disease

J Säfwenberg, U Backman, B G Danielson

    Scandinavian Journal of Urology and Nephrology
    |January 1, 1978
    PubMed
    Summary

    This study investigated the association between Human Leukocyte Antigen (HLA) types and kidney stones in normocalcemic patients. While some HLA phenotypes showed increased frequency, the findings were not statistically significant after adjustments, suggesting no strong link.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Treatment of anaemia in inflammatory bowel disease with iron sucrose.

    Scandinavian journal of gastroenterology·2004
    Same author

    The use of pretransplant erythropoietin to normalize hemoglobin levels has no deleterious effects on renal transplantation outcome.

    Transplantation·2001
    Same author

    Normalization of haemoglobin concentration with recombinant erythropoietin has minimal effect on blood haemostasis.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2001
    Same author

    Effect of normalization of hematocrit on brain circulation and metabolism in hemodialysis patients.

    Journal of the American Society of Nephrology : JASN·1999
    Same author

    Kinetic analysis of 52Fe-labelled iron(III) hydroxide-sucrose complex following bolus administration using positron emission tomography.

    British journal of haematology·1999
    Same author

    Pharmacokinetics and red cell utilization of iron(III) hydroxide-sucrose complex in anaemic patients: a study using positron emission tomography.

    British journal of haematology·1999

    Area of Science:

    • Immunogenetics
    • Nephrology
    • Urology

    Background:

    • Kidney stones are a common condition with complex etiologies.
    • Idiopathic hypercalciuria is a significant risk factor for calcium-based kidney stones.
    • Human Leukocyte Antigen (HLA) system plays a crucial role in immune response and has been implicated in various diseases.

    Purpose of the Study:

    • To investigate the potential association between specific Human Leukocyte Antigen (HLA) phenotypes and the occurrence of kidney stones in normocalcemic patients.
    • To determine if HLA antigen distribution differs in patients with idiopathic hypercalciuria compared to controls.
    • To explore HLA antigen distribution in patients with renal tubular acidosis and those without a clear metabolic diagnosis.

    Main Methods:

    • Human Leukocyte Antigen (HLA) typing was performed on normocalcemic patients with recurrent kidney stones.
    • Patients were categorized into groups: idiopathic hypercalciuria without renal tubular defect, renal tubular acidosis, and no metabolic diagnosis.
    • Phenotype frequencies of HLA antigens in patient groups were compared to control groups.

    Main Results:

    • A B27 phenotype frequency more than double that of controls and a doubled CW1 frequency were observed in 54 patients with idiopathic hypercalciuria.
    • These observed increases in HLA B27 and CW1 frequencies were not statistically significant after correction for the number of tested HLA specificities.
    • No significant deviations in HLA antigen distribution were found in 35 patients with renal tubular acidosis or 16 patients with no metabolic diagnosis.

    Conclusions:

    • The study found no statistically significant association between HLA antigen distribution and kidney stone formation in normocalcemic patients, even in those with idiopathic hypercalciuria.
    • The observed higher frequencies of HLA B27 and CW1 in the idiopathic hypercalciuria group did not reach statistical significance, indicating these are unlikely to be major genetic risk factors.
    • HLA typing does not appear to be a significant diagnostic or predictive tool for kidney stone disease in the studied normocalcemic populations.

    Related Experiment Videos