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[Missing thrombinemia in the so-called hypercoagulability following physical exertion (proceedings)]
Schweizerische Medizinische Wochenschrift
|October 14, 1978
Summary
Strenuous exercise activates blood coagulation and fibrinolysis in healthy individuals. However, this activation does not involve fibrinogen conversion to fibrin, as indicated by the absence of fibrinopeptide A generation.
Area of Science:
- Physiology
- Hematology
Context:
- Stress and exercise are known to affect hemostasis.
- The relationship between stress, hypercoagulability, and hyperfibrinolysis remains debated.
Purpose:
- To investigate the hemostatic response to strenuous physical exertion.
- To determine if exercise-induced hypercoagulability involves fibrinogen conversion.
Summary:
- Ten healthy volunteers underwent strenuous exercise, with blood samples collected pre- and post-exertion.
- Coagulation tests showed significant activation (shortened APTT, thrombin, and reptilase times), but no fibrinopeptide A (FPA) generation.
- Fibrinolysis showed activation (shortened euglobulin lysis time), yet no fibrin(ogen) degradation products (FDP) were detected.
Impact:
- Suggests that exercise-induced hypercoagulability is not mediated by thrombin-dependent fibrinogen conversion.
- Highlights a dissociation between coagulation activation markers and fibrin formation/breakdown products.
- Provides insights into the mechanisms of hemostatic changes during physical stress.