[Morphological characteristics of osteogenic sarcoma after chemo-and radiotherapy]

Adriamycin was administered intraarterially and the tumor was irradiated at a total focal dose of 3600 rad in the preoperational period in 25 children suffering from osteogenic sarcoma. Histological examinations of the tumors revealed marked necrobiotic, necrotic and sclerotic changes. Within 2 months after the beginning of the therapy the number of tumor cells decreased, they were localized predominantly in the peripheral parts of the extraosseal component. Later in the same areas new generations of tumor cells were found. In 3 cases tumor cells were completely absent. The results suggest the efficacy of adriamycin in combination with radiation therapy in treatment of osteogenic sarcoma.