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Related Experiment Videos

Decrease of human serum fucosyltransferase as an indicator of successful tumor therapy

C H Bauer, W G Reutter, K P Erhart

    Science (New York, N.Y.)
    |September 29, 1978
    PubMed
    Summary
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    Measuring fucosyltransferase activity can help diagnose cancer and monitor treatment effectiveness. Surgical removal of colon cancer normalized incorporation rates, indicating potential for therapeutic assessment.

    Area of Science:

    • Biochemistry
    • Oncology
    • Clinical Diagnostics

    Background:

    • Colon carcinoma surgery impacts fucosylation in human serum.
    • Fucosyltransferase activity is linked to therapeutic response in breast cancer patients.

    Purpose of the Study:

    • To investigate the diagnostic potential of fucosyltransferase activity.
    • To correlate fucosyltransferase activity with cancer treatment outcomes.

    Main Methods:

    • Measuring [14C]fucose incorporation into endogenous acceptors in human serum post-surgery.
    • Assessing alpha2- and alpha3-fucosyltransferase activity using exogenous acceptors.
    • Correlating transferase activity with patient therapeutic response.

    Main Results:

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    • Surgical removal of colon carcinomas decreased [14C]fucose incorporation.
    • Normal incorporation rates were restored within 14 days post-surgery.
    • Fucosyltransferase activity correlated with breast cancer treatment success.

    Conclusions:

    • Fucosyltransferase activity determination aids in neoplasia diagnosis.
    • This activity measurement can monitor the success of surgery, chemotherapy, and radiation therapies.