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Mixed invasive infection with Alternaria species and Curvularia species
American Journal of Clinical Pathology
|October 1, 1981
Abstract:
Alternaria and Curvularia species were isolated from the nasal septum of a neutropenic patient and tissue invasion was documented histologically. The patient recovered without the use of systemic antifungal agents following surgical excision of the nasal septum and spontaneous resolution of neutropenia.
Insights
Fungal sinusitis caused by Alternaria and Curvularia species in a neutropenic patient resolved with surgical intervention and immune system recovery. Systemic antifungal therapy was not required for this nasal septum fungal infection.
Area of Science:
- Mycology
- Infectious Diseases
- Surgical Pathology
Background:
- Neutropenia significantly increases susceptibility to opportunistic fungal infections.
- Fungal sinusitis can present as a severe invasive disease in immunocompromised individuals.
Observation:
- Alternaria and Curvularia species were identified in the nasal septum of a neutropenic patient.
- Histological examination confirmed tissue invasion by the fungi.
Findings:
- The patient experienced complete recovery following surgical excision of the affected nasal septum.
- Resolution of neutropenia and surgical treatment were key to the patient's recovery.
- Systemic antifungal agents were not administered.
Implications:
- Surgical management can be effective for localized invasive fungal sinusitis in neutropenic patients.
- Spontaneous resolution of neutropenia can aid in overcoming fungal infections.
- This case highlights the importance of considering surgical intervention in specific invasive fungal infections.