[Adenohypophyseal ultrastructural in mice administered prostaglandin F2 alpha]

Adenohypophyses of white non-inbred cycling mice, which were given prostaglandin F2 alpha (total dose, 240 mkg) for 4 days beginning from metaestrus, were studied at electron microscopic, light optic levels and by means of immune peroxidase reaction. Due to prostaglandin F2 alpha administration, functional activity of lactotropocytes, somatotropocytes, luteinizing gonadotropocytes was increased, and activity of follicle-stimulating gonadotropocytes was inhibited. At the same time, a certain type of actively functioning somatotropocytes was detected which did not react to the experimental stimulation. The number of lactotropocytes and luteinizing gonadotropocytes increased, as well as proliferative activity of the adenohypophyseal parenchyma. Taking into account the variable changes of the adenohypophysis mentioned above, it is possible to suggest its specific reaction as a whole organ to administration of prostaglandin F2 alpha. The data obtained could explain the multiformity of hormonal shifts (known from the literature) occurring in the organism after prostaglandin F2 alpha administration.