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Chronic myelocytic leukaemia: a pluripotent haemopoietic cell is involved in the malignant clone

D Douer, A M Levin, R S Sparkes

    British Journal of Haematology
    |December 1, 1981
    PubMed

    Haemopoietic cells with pluripotent capabilities, were grown in soft-gel cultures from the peripheral blood of a glucose-6-phosphate dehydrogenase (G6PD) electrophoretic A,B heterozygous female with chronic myelocytic and granulocytic progeny. Only type B isoenzyme of G6PD was found in mixed colonies, in mature neutrophils, erythrocytes, and committed granulocyte and isoenzymes of G6PD. This study provides direct evidence that a pluripotent haemopoietic stem cell is involved in the malignant clone in CML.

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