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Hemostatic function tests associated with diabetic microangiopathy

J H Fuller

    Hormone and Metabolic Research. Supplement Series
    |January 1, 1981
    PubMed
    Summary
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    Diabetics show higher blood clotting factors and lower clot breakdown, suggesting a link between thrombosis and diabetes complications. Further research is needed to confirm if this tendency causes microangiopathy.

    Area of Science:

    • Cardiovascular Medicine
    • Hematology
    • Endocrinology

    Background:

    • Diabetes mellitus is associated with an increased risk of vascular complications.
    • Hemostatic function may play a role in the development of these complications.

    Purpose of the Study:

    • To investigate the association between thrombotic tendency and vascular complications in diabetic patients.
    • To compare hemostatic function in diabetics with a control group.

    Main Methods:

    • Hemostatic function tests (factor VII, fibrinogen, antithrombin III, platelet adhesiveness, fibrinolytic activity) were performed on 154 diabetic patients (91 men, 63 women, aged 35-54).
    • Results were compared with 1076 individuals from the Northwick Park Heart Study.

    Main Results:

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    • Diabetic patients exhibited higher levels of factor VII, fibrinogen, antithrombin III, and platelet adhesiveness, alongside lower fibrinolytic activity compared to controls.
    • Diabetics with retinopathy showed elevated factor VII and antithrombin III.
    • Diabetics with proteinuria had higher factor VII, fibrinogen, and platelet adhesiveness.

    Conclusions:

    • The findings suggest a significant association between increased thrombotic tendency and microangiopathy in diabetes.
    • Prospective studies are required to establish a causal relationship between these hemostatic changes and diabetic vascular complications.