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Related Experiment Videos

Endotoxic activity in periapical lesions

S E Schonfeld, A B Greening, D H Glick

    Oral Surgery, Oral Medicine, and Oral Pathology
    |January 1, 1982
    PubMed
    Summary

    Bacterial endotoxins are linked to apical granulomas. This study found endotoxin in 75% of inflamed tissues, compared to only 20% of non-inflamed tissues, suggesting a strong correlation between endotoxin presence and inflammation.

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    Area of Science:

    • Oral pathology
    • Microbiology
    • Immunology

    Background:

    • Apical granulomas are inflammatory lesions at the root apex of teeth.
    • Endotoxins, components of bacterial cell walls, are known potent inflammatory stimuli.

    Purpose of the Study:

    • To investigate the correlation between the presence of endotoxin and histological evidence of inflammation in periapical tissues.
    • To determine if endotoxin is a significant factor in the pathogenesis of apical granulomas.

    Main Methods:

    • Histological examination of 30 periapical tissue samples to classify them as inflamed (apical granulomas) or noninflamed (scars/cysts).
    • Homogenization of tissue samples and treatment to remove interfering substances.
    • Determination of endotoxin presence using the Limulus assay.

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    Main Results:

    • Endotoxin was detected in 75% of inflamed tissues (apical granulomas).
    • Endotoxin was detected in only 20% of noninflamed tissues (scars or noninflamed cysts).
    • A statistically significant correlation (p = 0.015) was found between endotoxin presence and tissue inflammation.

    Conclusions:

    • The findings strongly suggest that bacterial endotoxins play a significant role in the development or perpetuation of apical granulomas.
    • Endotoxin detection may serve as a valuable biomarker for inflammatory periapical lesions.