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Red cell filterability in diabetes

Y Isogai, K Mochzuki, T Maeda

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1981
    PubMed
    Summary
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    Diabetes impairs red blood cell filterability (RCF), particularly in advanced retinopathy. Pentoxifylline shows promise in improving RCF and microcirculation in diabetic patients.

    Area of Science:

    • Hematology
    • Diabetology
    • Microcirculation Research

    Background:

    • Diabetes mellitus is associated with altered red blood cell properties.
    • Reduced red blood cell filterability (RCF) is a potential complication in diabetes.
    • Microvascular complications in diabetes may be linked to impaired red blood cell deformability.

    Purpose of the Study:

    • To investigate the relationship between glycemic control and RCF in diabetes.
    • To assess the impact of diabetic retinopathy on RCF.
    • To evaluate the potential therapeutic effect of Pentoxifylline on RCF and microcirculation in diabetes.

    Main Methods:

    • Developed a negative pressure red cell filtration technique using polycarbonate sieves (Nuclepore).
    • Measured RCF in patients with diabetes, correlating it with HbA1c levels and retinopathy status.

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  • Assessed the effect of Pentoxifylline on red cell suspensions in vitro.

    • Main Results:

    • A significant negative correlation was found between increased HbA1c and decreased RCF.
    • Diabetic patients with advanced retinopathy exhibited a greater decrease in RCF.
    • Increased 2,3-diphosphoglycerate (2,3-DPG) was observed in diabetic red cells, with minimal change in P50.
    • Addition of Pentoxifylline improved RCF in red cell suspensions.

    Conclusions:

    • Elevated HbA1c levels are closely linked to reduced red blood cell filterability in diabetes.
    • Diabetic retinopathy severity correlates with the degree of RCF impairment.
    • Pentoxifylline demonstrates potential for improving microcirculation in diabetes by enhancing red blood cell filterability.