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Red cell filterability and chronic renal failure

A Decamps, M Zandecki, M Ribière

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1981
    PubMed
    Summary
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    Red blood cell filterability is significantly reduced in patients with chronic renal failure. Filtration time correlates with hemoglobin levels, not the severity of uremia.

    Area of Science:

    • Nephrology
    • Hematology
    • Biomedical Engineering

    Background:

    • Chronic renal failure (CRF) is associated with various complications affecting blood properties.
    • Red blood cell (RBC) deformability is crucial for microcirculation and oxygen delivery.
    • Impaired RBC filterability may contribute to the pathophysiology of uremia.

    Purpose of the Study:

    • To investigate red blood cell filterability in patients with chronic renal failure.
    • To explore the relationship between RBC filterability and the degree of uremia.
    • To determine factors influencing RBC filtration time in uremic patients.

    Main Methods:

    • RBCs from CRF patients (creatinine > 350 µmol/l) were washed and adjusted to a packed cell volume (PCV) of 0.3.
    • Filtration was performed using polycarbonate sieves with 5 µm pores.

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  • Washing solutions included 9 g/l NaCl or 40 g/l human serum albumin.

    • Main Results:

    • RBC filterability in uremic patients was heterogeneous, showing a significant reduction compared to controls (implied).
    • Filtration time did not strongly correlate with the creatinine level (degree of uremia).
    • Filtration time showed a correlation with the hemoglobin level in the uremic patient group.

    Conclusions:

    • Red blood cell filterability is impaired in chronic renal failure.
    • Hemoglobin levels, rather than the severity of uremia, appear to be a key determinant of RBC filtration time.
    • These findings suggest potential mechanisms for microcirculatory disturbances in uremia.