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Red blood cell filterability in non-diabetic patients with chronic occlusive arterial disease
Insights
Red blood cell filterability (RBF) is impaired in patients with chronic occlusive arterial disease (COAD). This reduced RBF correlates with elevated white blood cell counts, hematocrit, and fibrinogen levels.
Area of Science:
- Vascular Biology
- Hematology
Background:
- Chronic occlusive arterial disease (COAD) affects blood flow and oxygen delivery.
- Red blood cell (RBC) deformability is crucial for microcirculation.
- Impaired RBC filterability may contribute to COAD pathophysiology.
Purpose of the Study:
- To assess red blood cell filterability (RBF) in non-diabetic patients with stage II COAD.
- To identify potential correlations between RBF and various hematological and biochemical parameters.
Main Methods:
- Compared RBF in 150 COAD patients and 30 healthy controls using the Reid & Dormandy technique with 5 micrometer filters.
- Measured parameters included glycaemia, uricaemia, plasma lipids, fibrinogen, hematocrit, and white blood cell counts.
Main Results:
- COAD patients exhibited significantly reduced RBF (41.97 ± 0.89 s.ml⁻¹) compared to controls (32.1 ± 1.33 s.ml⁻¹; P < 0.005).
- RBF alterations significantly correlated with white blood cell count (P < 0.05), hematocrit (P < 0.05), and plasma fibrinogen (P < 0.05).
- No significant correlation was found between RBF and glycaemia, uricaemia, plasma cholesterol, or triglycerides.
Conclusions:
- Red blood cell filterability is compromised in patients with stage II COAD.
- Hematological factors like white blood cell count, hematocrit, and fibrinogen are associated with impaired RBF in this patient group.
Abstract:
One-hundred and fifty non-diabetic patients with stage II chronic occlusive arterial disease (COAD), were tested for red blood cell filterability (RBF). At the same time, glycaemia, uricaemia, plasma cholesterol and triglycerides, fibrinogen, haematocrit, and white blood cells (granulocytes and lymphocytes) count, mean corpuscular volume, were measured. Thirty healthy people, tested for the same biological parameters, were used as controls. RBF was performed, using the Reid & Dormandy technique, with the same batch of filters (Nuclepore 5 micrometer, No. 54 A8 A25) for patients and controls. Filtration time was expressed in s.ml-1. Values obtained in patients (41.967 +/- 0.889) were significantly different (P less than 0.005) from controls (32.1 +/- 1.329). RBF alteration was correlated (P less than 0.05) with white blood cells count, haematocrit and plasma fibrinogen values. No correlation was observed with other biological parameters.