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Filterability in children

J Delobel, T Iaru, M A Herve

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1981
    PubMed

    Insights

    Erythrocyte filterability in children differs significantly from adults, suggesting an unknown factor influences red blood cell deformability in younger individuals. Further research is needed to identify these factors.

    Area of Science:

    • Hematology
    • Pediatric Medicine
    • Biophysics

    Background:

    • Blood and erythrocyte (red blood cell) filterability are crucial indicators of hemorheological properties.
    • Understanding age-related differences in filterability is important for pediatric health assessments.

    Purpose of the Study:

    • To investigate and compare the filterability of total blood and erythrocytes in children and adults.
    • To identify potential correlations between erythrocyte filterability and various physiological factors in children.

    Main Methods:

    • The study utilized the Reid filtration method to assess filterability.
    • Erythrocytes were isolated via centrifugation, washed, and resuspended in saline for testing.
    • Filtration time for 1 ml of total blood and erythrocyte suspension was recorded.

    Main Results:

    • Children (2-14 years) exhibited significantly longer filtration times for total blood (49.10 ± 14.5 s/ml) and erythrocyte suspensions (18.19 ± 6.16 s/ml) compared to adults (33.04 ± 7.40 s/ml and 13.99 ± 2.95 s/ml, respectively).
    • No significant correlation was found between erythrocyte filterability and age, fibrinogen, white blood cells, glycaemia, or haematocrit in the studied children.
    • The observed differences in filterability between children and adults were statistically significant.

    Conclusions:

    • Children's erythrocytes demonstrate notably reduced filterability compared to adults.
    • The reduced filterability in children is not explained by the investigated hematological or clinical parameters.
    • An unidentified factor likely influences erythrocyte filterability in pediatric populations.

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